Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Understanding how a potential drug is metabolised in the liver is a critical first step in early-stage drug development - but ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

It often involves the introduction of genetic material into a person’s cells to replace a defective or missing gene. Although early attempts at gene therapy have been effective in achieving the ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...

Humanized mouse models are vital for studying human gene function, but fully replacing mouse genes with complete human ...